Cincinnati’s Spencer Steer crosses home plate and celebrates with Kevin Newman after his two-run home run against the Boston Red Sox during the seventh inning Wednesday in Boston. At right is Red Sox catcher Connor Wong. Charles Krupa/Associated Press

BOSTON — Spencer Steer hit a two-run homer to break a seventh-inning tie and the Cincinnati Reds took advantage of Rafael Devers’ throwing error to come from behind and beat the Boston Red Sox 5-4 on Wednesday night.

Kevin Newman, Matt McLain and Nick Senzel had two hits apiece for the Reds, who have won five in a row, taking the first two of their three games in Boston to beat the Red Sox in a series for the first time since the 1975 World Series.

Ian Gibaut (5-1) pitched one inning of perfect relief for Cincinnati, which trailed 2-0 and 3-1 before scoring one in the sixth and three unearned runs off Josh Winckowski (2-1) in the seventh to take a 5-3 lead. Buck Farmer pitched the ninth, retiring Devers on a deep fly to center to end it and earn his first save.

Masataka Yoshida curled a home run around the Pesky Pole and Emmanuel Valdez landed one on the shelf atop the Green Monster for Boston. Devers and Jarren Duran had RBI doubles.

Boston led 3-1 after five and 3-2 through six before Luke Maile led off the seventh with a hard chopper to third base and Devers one-hopped the throw past first baseman Justin Turner. Newman and McLain singled to load the bases, then one run scored on Jonathan India’s double play groundout.

Steer cleared the Green Monster with his eighth homer of the year to make it 5-3.

The Red Sox loaded the bases in the bottom half, but Alex Young got Turner to ground out to short to end the threat. Duran’s double made it 5-4 in the eighth, but Lucas Sims got Raimel Tapia on a lineout to center and then struck out Valdez to strand Duran at second.

James Paxton allowed one run on four hits and a walk, striking out eight in five innings for Boston. He left with a 3-1 lead.